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Most Runs
With 302 runs at a strike rate of 151, Hyderabad's Tanmay Agarwal leads the runs chart in the 2021 Syed Mushtaq Ali Trophy. He is followed by Deepak Hooda (291 at 175), Ajinkya Rahane (286 at 134) and Ashwin Hebbar (279 at 133). Manan Vohra is at fifth place, with 273 at 131, while Sheldon Jackson (271 at 142) moved to sixth position with a fifty against Karnataka, on 16 November.
| Batters | M | R | AVG | SR |
| Tanmay Agarwal | 5 | 302 | 75.5 | 151 |
| Deepak Hooda | 5 | 291 | 97 | 175.3 |
| Ajinkya Rahane | 5 | 286 | 57.2 | 133.64 |
| Ashwin Hebbar | 5 | 279 | 93 | 133.49 |
| Manan Vohra | 5 | 273 | 68.25 | 130.62 |
| Sheldon Jackson | 6 | 271 | 67.75 | 141.88 |
Most Wickets
With 16 scalps at an economy rate of 9.02, Chama Milind is at the top of the wickets tally. C. Stephen and Rishi Dhawan are tied on second place, with 14 wickets apiece, while Jaydev Unadkat (13 at 6.41) and Akshay Karnewar (12 at 3.87) moved up in this chart after returning 4-22 and 2-25 in their respective preliminary quarter-final matches. Amit Ali occupies fifth place, with 11 wickets at 4.68.
| Bowlers | M | O | W | AVG | 4W+ |
| Chama V Milind | 5 | 18.5 | 16 | 10.62 | 2 |
| C. Stephen | 5 | 19.5 | 14 | 9.07 | 1 |
| Rishi Dhawan | 6 | 21.5 | 14 | 11.14 | 1 |
| Jaydev Unadkat | 6 | 24 | 13 | 11.85 | 1 |
| Akshay Karnewar | 6 | 24 | 12 | 7.75 | 1 |
| Amit Ali | 5 | 19 | 11 | 8.09 | 1 |